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Generic Name: chromium picolinate (KROME ee um pi KOE li nate)
Brand Name:Cr-GTF, CRM, Chromium GTF
Dosage Forms: oral capsule (200 mcg); oral tablet (200 mcg; 500 mcg; 800 mcg)

Best Chromium Picolinate Supplement

What is chromium picolinate?

Unlike other trivalent chromium compounds, chromium picolinate is soluble in water at neutral pH. Chromium Picolinate supports a healthy metabolism to keep your weight at healthy levels. Unlike other trivalent chromium compounds, chromium picolinate is soluble in water at neutral pH. Chromium Picolinate supports a healthy metabolism to keep your weight at healthy levels. Chromium picolinate is an essential trace mineral, meaning that only small amounts are required for good health. One form, chromium picolinate, is popular because it is one of the more easily absorbed forms. Research on the benefits of chromium to enhance fat loss and increase performance in bodybuilders and athletes has provided mixed results. Like many essential minerals, there are various forms of zinc and zinc picolinate is the most bioavailable and useful for the brain. The zinc is chelated with picolinate, which allows the body to more easily break it down and yield elemental zinc. Zinc acts as a potent anti-inflammatory, antioxidant, and helps to boost immune health.

Chromium is a mineral found in certain foods. The body needs only trace amounts of chromium, and deficiency of this mineral in humans is rare.

Chromium picolinate works together with insulin produced by the pancreas to metabolize carbohydrates.

Chromium picolinate has been used in alternative medicine to treat chromium deficiency, as an aid to controlling blood sugar in people with diabetes or prediabetes, to lower cholesterol, and as a weight-loss supplement.

Not all uses for chromium picolinate have been approved by the FDA. Chromium picolinate should not be used in place of medication prescribed for you by your doctor.

Chromium picolinate is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Chromium picolinate may also be used for purposes not listed in this product guide.


Follow all directions on the product label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Picolinate Meaning

Before taking this medicine

Before using chromium picolinate, talk to your healthcare provider. You may not be able to use chromium picolinate if you have certain medical conditions.

  • liver disease;

  • kidney disease;

  • diabetes (especially if you use insulin);

  • an allergy to leather products;

  • mental illness;

  • a thyroid disorder; or

  • if you use steroid medicine (fluticasone, beclomethasone, prednisone, and others).

It is not known whether chromium picolinate will harm an unborn baby. Do not use this product without medical advice if you are pregnant.

Chromium picolinate may pass into breast milk and may harm a nursing baby. Do not use this product without medical advice if you are breast-feeding a baby.

Do not give any herbal/health supplement to a child without medical advice.

How should I take chromium picolinate?

When considering the use of herbal supplements, seek the advice of your doctor. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements.

If you choose to use chromium picolinate, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Do not use more of this product than is recommended on the label.

Check your blood sugar carefully if you are diabetic.

The recommended dietary allowance of chromium picolinate increases with age. Follow your healthcare provider's instructions. You may also consult the National Academy of Sciences 'Dietary Reference Intake' or the U.S. Department of Agriculture's 'Dietary Reference Intake' (formerly 'Recommended Daily Allowances' or RDA) listings for more information.

Chromium picolinate may be only part of a treatment program that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very carefully.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include vomiting, diarrhea, blood in your urine or stools, or coughing up blood.

What should I avoid while taking chromium picolinate?

Avoid a diet that is high in sugar. It may interfere with the effectiveness of chromium picolinate.

Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for your body to absorb chromium picolinate.

Chromium picolinate side effects

Get emergency medical help if you have signs of an allergic reaction:hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using chromium picolinate and call your doctor at once if you have:

  • thinking problems, trouble concentrating;

  • problems with balance or coordination; or

  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • headache;

  • sleep problems (insomnia); or

  • mood changes, feeling irritable.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Chromium picolinate side effects(more detail)

What other drugs will affect chromium picolinate?

Other drugs may interact with chromium picolinate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Chromium picolinate drug interactions(more detail)

More about chromium picolinate

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Further information

  • Consult with a licensed healthcare professional before using any herbal/health supplement. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2021 Cerner Multum, Inc. Version: 2.02.

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Zinc Picolinate Side Effects

Picolinic acid
Preferred IUPAC name
Other names
Picolinic acid
  • 98-98-6
  • ChEMBL72628
ECHA InfoCard
  • QZV2W997JQ
  • InChI=1S/C6H5NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H,(H,8,9)
  • InChI=1/C6H5NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H,(H,8,9)
  • c1ccnc(c1)C(=O)O
Molar mass123.111 g·mol−1
AppearanceWhite to tan crystalline solid
Melting point 136 to 138 °C (277 to 280 °F; 409 to 411 K)
Slightly soluble (0.41%) in water[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references


Picolinate definition

Picolinic acid is an organic compound with the formula C5H4N(CO2H). It is a derivative of pyridine with a carboxylic acid (COOH) substituent at the 2-position. It is an isomer of nicotinic acid and isonicotinic acid, which have the carboxyl side chain at the 3- and 4-position, respectively. It is a white solid that is soluble in water.

In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.[2]:495ff

Coordination chemistry[edit]

Picolinate neuro

Picolinic acid is a bidentate chelating agent of elements such as chromium, zinc, manganese, copper, iron, and molybdenum in the human body.[3]:72 Many of its complexes are charge-neutral and thus lipophilic. After its role in absorption was discovered, zinc dipicolinate dietary supplements became popular as they were shown to be an effective means of introducing zinc into the body.[3]


Picolinic acid is formed from 2-methylpyridine by oxidation, e.g. by means of potassium permanganate (KMnO4).[4][5]


Picolinic acid is a catabolite of the amino acid tryptophan through the kynurenine pathway.[3][6] Its function is unclear, but it has been implicated in a variety neuroprotective, immunological, and anti-proliferative effects. In addition, it is suggested to assist in the absorption of zinc(II) ions and other divalent or trivalent ions through the small intestine.[7]


Salts of picolinic acid (picolinates) include:

See also[edit]


  1. ^Lide, DR. 'CRC Handbook of Chemistry and Physics, Internet Version 2005, http://hbcpnetbase.com, CRC Press, Boca Raton, Florida, 2005'.Cite journal requires journal= (help)
  2. ^Picolinic Acid chapter in Philip L. Fuchs. Handbook of Reagents for Organic Synthesis: Catalytic Oxidation Reagents. John Wiley & Sons, Jul 29, 2013 ISBN9781118704820
  3. ^ abcGrant, RS; Coggan, SE; Smythe, GA (2009). 'The physiological action of picolinic Acid in the human brain'. International Journal of Tryptophan Research : IJTR. 2: 71–9. doi:10.4137/ijtr.s2469. PMC3195224. PMID22084583.
  4. ^Shimizu, Shinkichi; Watanabe, Nanao; Kataoka, Toshiaki; Shoji, Takayuki; Abe, Nobuyuki; Morishita, Sinji; Ichimura, Hisao (2007). 'Pyridine and Pyridine Derivatives'. Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a22_399.
  5. ^Harold Hart (Autor), Leslie E. Craine (Autor), David J. Hart (Autor), Christopher M. Hadad (Autor); Nicole Kindler (Übersetzer): Organische Chemie, 3. Auflage, Wiley-VCH, Weinheim 2007, ISBN978-3-527-31801-8, S. 494.
  6. ^Tan, L.; et al. (December 2012). 'The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations'. J Neurol Sci. 323 (1–2): 1–8. doi:10.1016/j.jns.2012.08.005. PMID22939820.
  7. ^Evans, Gary (1982). 'The Role of Picolinic Acid in Metal Metabolism'. Life Chemistry Reports. Harwood Academic Publishers. 1: 57–67. Retrieved 20 March 2015.
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