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Structural basis of cargo recognitions for class V myosins

Wei, Z., Liu, X., Yu, C., Zhang, M.Myova

MyoVa directly mediates stable attachment of secretory granules at the plasma membrane. Present a kinetic model for the walking of myosin V on actin role of function in melanosome transport Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a. Myth 1 Busted: Taking Myo-Inositol For Weight Loss. The first thing I want to point out is that if you. MyNova The MyNova portal allows users to have access to many of Villanova's applications such as email, Banner, Blackboard, Novasis, and much more without having to separately log into those applications. The portal can be reached at http://mynova.villanova.edu.

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(2013) Proc Natl Acad Sci U S A 110: 11314-11319

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  • PubMed: 23798443Search on PubMedSearch on PubMed Central
  • DOI: 10.1073/pnas.1306768110
  • Primary Citation of Related Structures:
    3WB8, 4KP3

  • PubMed Abstract:
  • Class V myosins (MyoV), the most studied unconventional myosins, recognize numerous cargos mainly via the motor's globular tail domain (GTD). Little is known regarding how MyoV-GTD recognizes such a diverse array of cargos specifically. Here, we solved the crystal structures of MyoVa-GTD in its apo-form and in complex with two distinct cargos, melanophilin and Rab interacting lysosomal protein-like 2 ...

    Class V myosins (MyoV), the most studied unconventional myosins, recognize numerous cargos mainly via the motor's globular tail domain (GTD). Little is known regarding how MyoV-GTD recognizes such a diverse array of cargos specifically. Here, we solved the crystal structures of MyoVa-GTD in its apo-form and in complex with two distinct cargos, melanophilin and Rab interacting lysosomal protein-like 2. The apo-MyoVa-GTD structure indicates that most mutations found in patients with Griscelli syndrome, microvillus inclusion disease, or cancers or in 'dilute' rodents likely impair the folding of GTD. The MyoVa-GTD/cargo complex structure reveals two distinct cargo-binding surfaces, one primarily via charge-charge interaction and the other mainly via hydrophobic interactions. Structural and biochemical analysis reveal the specific cargo-binding specificities of various isoforms of mammalian MyoV as well as very different cargo recognition mechanisms of MyoV between yeast and higher eukaryotes. The MyoVa-GTD structures resolved here provide a framework for future functional studies of vertebrate class V myosins.

    Organizational Affiliation:

    Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China.


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MyoVa performs the role of melanosome trafficking in melanocytes.8 However, depletion of any one of the components of the tripartite complex causes perinuclear aggregation of melano - somes because of the defect in melanosome transport from the peri - nuclear space to dendrite tips.9 According to a recent study, Rab27a- Mlph and Mlph- MyoVa. Myovant (MYOV) and Pfizer (PFE) initiate dosing in the phase III SERENE study evaluating the contraceptive efficacy of the relugolix combination tablet. GlobeNewswire.