Chromium Picolinate

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  1. Chromium Picolinate And Cinnamon
  2. Chromium Picolinate Supplement
  3. Chromium Picolinate And Cinnamon
Picolinic acid
Names
Preferred IUPAC name
Other names
Picolinic acid
Identifiers
  • 98-98-6
ChEBI
ChEMBL
  • ChEMBL72628
ChemSpider
ECHA InfoCard
PubChemCID
UNII
  • QZV2W997JQ
  • InChI=1S/C6H5NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H,(H,8,9)
  • InChI=1/C6H5NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H,(H,8,9)
  • c1ccnc(c1)C(=O)O
Properties
C6H5NO2
Molar mass123.111 g·mol−1
AppearanceWhite to tan crystalline solid
Melting point 136 to 138 °C (277 to 280 °F; 409 to 411 K)
Slightly soluble (0.41%) in water[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
  1. Bid Date WIN(s) Municipality Description Date Posted/ Updated; 5/5/2021: 024865.00 & 024871.00: Townships of Taunton & Raynham Academy Grant - Rockwood Strip T1 R1 NBKB & Big Moose - Region 3.
  2. Chromium helps the body regulate blood sugar levels by transporting glucose to cells. Chromium also works with other trace elements in breaking down proteins, fats and carbohydrates. Two chromium supplements are available for consumption; chromium picolinate and glucose-tolerance factor. Symptoms of Chromium Deficiency.
  3. Chromium Picolinate. Chromium is a mineral that enhances insulin, a hormone that's important for turning food into energy. Your body also needs it to store carbohydrates, fats, and proteins.

Chromium Picolinate And Cinnamon

Picolinic acid is an organic compound with the formula C5H4N(CO2H). It is a derivative of pyridine with a carboxylic acid (COOH) substituent at the 2-position. It is an isomer of nicotinic acid and isonicotinic acid, which have the carboxyl side chain at the 3- and 4-position, respectively. It is a white solid that is soluble in water.

Chromium is an essential trace mineral that helps the hormone insulin to function at its full potential. Nicotinate and picolinate are two forms of chromium. Proponents of the picolinate form claim that it lowers cholesterol, burns body fat, and increases life span. Chromium picolinate is a popular supplement often marketed to those wanting to build muscle or lose weight. Some bodybuilders and athletes take it to enhance performance and increase energy.

In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.[2]:495ff

Coordination chemistry[edit]

Picolinic acid is a bidentate chelating agent of elements such as chromium, zinc, manganese, copper, iron, and molybdenum in the human body.[3]:72 Many of its complexes are charge-neutral and thus lipophilic. After its role in absorption was discovered, zinc dipicolinate dietary supplements became popular as they were shown to be an effective means of introducing zinc into the body.[3]

Production[edit]

Picolinic acid is formed from 2-methylpyridine by oxidation, e.g. by means of potassium permanganate (KMnO4).[4][5]

Biosynthesis[edit]

Chromium Picolinate Supplement

Picolinic acid is a catabolite of the amino acid tryptophan through the kynurenine pathway.[3][6] Its function is unclear, but it has been implicated in a variety neuroprotective, immunological, and anti-proliferative effects. In addition, it is suggested to assist in the absorption of zinc(II) ions and other divalent or trivalent ions through the small intestine.[7]

Picolinates[edit]

Chromium picolinate and cinnamon

Salts of picolinic acid (picolinates) include:

Chromium

Chromium Picolinate And Cinnamon

See also[edit]

References[edit]

  1. ^Lide, DR. 'CRC Handbook of Chemistry and Physics, Internet Version 2005, http://hbcpnetbase.com, CRC Press, Boca Raton, Florida, 2005'.Cite journal requires journal= (help)
  2. ^Picolinic Acid chapter in Philip L. Fuchs. Handbook of Reagents for Organic Synthesis: Catalytic Oxidation Reagents. John Wiley & Sons, Jul 29, 2013 ISBN9781118704820
  3. ^ abcGrant, RS; Coggan, SE; Smythe, GA (2009). 'The physiological action of picolinic Acid in the human brain'. International Journal of Tryptophan Research : IJTR. 2: 71–9. doi:10.4137/ijtr.s2469. PMC3195224. PMID22084583.
  4. ^Shimizu, Shinkichi; Watanabe, Nanao; Kataoka, Toshiaki; Shoji, Takayuki; Abe, Nobuyuki; Morishita, Sinji; Ichimura, Hisao (2007). 'Pyridine and Pyridine Derivatives'. Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a22_399.
  5. ^Harold Hart (Autor), Leslie E. Craine (Autor), David J. Hart (Autor), Christopher M. Hadad (Autor); Nicole Kindler (Übersetzer): Organische Chemie, 3. Auflage, Wiley-VCH, Weinheim 2007, ISBN978-3-527-31801-8, S. 494.
  6. ^Tan, L.; et al. (December 2012). 'The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations'. J Neurol Sci. 323 (1–2): 1–8. doi:10.1016/j.jns.2012.08.005. PMID22939820.
  7. ^Evans, Gary (1982). 'The Role of Picolinic Acid in Metal Metabolism'. Life Chemistry Reports. Harwood Academic Publishers. 1: 57–67. Retrieved 20 March 2015.
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